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Rejuran Healer, HB and Eye in Gangnam: Differences, Pain and Aftercare

Dr. Ha Jaeseon·2026.10.29·4 min read
Rejuran Healer, HB and Eye in Gangnam: Differences, Pain and Aftercare

Hello, I'm Dr. Ha Jaeseon, the medical director of PO:VE Clinic Dosan.

Rejuran is a representative skin booster that has been loved for a very long time.

In particular, I often receive questions about the differences between Healer/HB/Eye during consultations.

Today, I will consolidate the information that those considering Rejuran are most curious about all at once.

(This is a patient who received treatment at our clinic, and we have obtained consent for photo upload)

What is Rejuran Treatment?

Rejuran is an injection procedure that delivers a regenerative ingredient called PN (polynucleotide), derived from salmon, into the dermis (the layer responsible for skin elasticity). The principle is to create an environment for the skin to heal itself, aiming to improve skin texture, fine wrinkles, elasticity, and the skin barrier. Therefore, it is a treatment that often yields high satisfaction for those with sensitive skin or frequent breakouts.

Rejuran Healer vs. HB vs. Eye: What's the Difference?

Rejuran Healer is the original product containing only PN.

It is rich in regenerative ingredients and is well-suited when you want to focus on overall skin regeneration and elasticity.

The advantage is that since it contains only PN, you can receive a larger amount of PN. The disadvantage is that it is much more painful than HB. However, this can also be made much less painful with proper injection techniques and anesthesia.

Rejuran HB (HB Plus) is a product that adds hyaluronic acid (a moisturizing ingredient that retains moisture) and lidocaine (a local anesthetic ingredient) to PN. It is well-suited for those who want a dewy, hydrated feel or are concerned about the pain of Rejuran injections. The disadvantage is that the PN content is lower relative to the price.

Rejuran Eye is, as the name suggests, a product specifically for the eye area.

The skin around the eyes is the thinnest and most sensitive on the face, so the ingredients have been diluted to allow for smoother dispersion.

As a result, it causes less prominent "embossing" around the eyes and is effective in improving fine wrinkles and thinning skin texture around and under the eyes.

To summarize easily: "Focus on regeneration" is Healer, "Moisturization and reduced pain" is HB, and "Eye care" is Eye.

The combination varies depending on skin thickness and dryness, so I prefer to determine it after a personal consultation.

Is Rejuran Painful?

PN is a viscous ingredient, so the pain during injection tends to be greater compared to other skin booster injections.

Therefore, to reduce pain, it is important to wait until the anesthetic cream has fully penetrated and to inject small amounts in small portions with a very fine needle. Injecting in small portions significantly reduces the level of pain, and since the total amount injected is the same, the effect is also the same.

When Will I See Results and How Many Treatments Are Needed?

Immediately after the procedure, "embossing" (raised bumps) will appear at the injection sites, which usually subsides within one to two days. You will often start to notice improved skin texture as collagen fills in the skin around 2 to 4 weeks later.

Rejuran typically shows better results after 3 to 4 sessions at intervals of 2 to 4 weeks. Afterward, depending on your individual skin condition, it is recommended to have one maintenance treatment every 6 months to a year.

Are There Any Side Effects?

Common reactions include embossing, redness, mild bruising, and swelling, most of which disappear within a few days. Serious side effects are very rare, making it one of the safest procedures. However, if you have a fish allergy, there is a possibility of an allergic reaction, so it is important to inform your doctor beforehand.

Post-Treatment Precautions

On the day of the procedure, avoid rubbing the treated area. Light makeup is acceptable from the next day. For about 3 days, refrain from saunas, alcohol, and strenuous exercise. It is also recommended to diligently apply sunscreen.

How to Achieve Optimal Results?

The key to achieving good results is to select the Rejuran product that best suits you and to administer it using the appropriate technique.

Therefore, it is best to have an accurate assessment of your current condition through a consultation with a doctor and receive a recommended treatment plan.

Thank you for reading this long post.

#Skin/Skin Boosters
Translated from the clinic’s Naver Blog. The Korean original is the reference text.Read the original on Naver Blog →
WRITTEN BY
Ha Jaeseon · Doctor

Family Medicine Specialist, Korea University Hospital.
Leads clinical practice at PO:VE on the principles of comfortable recovery and beauty that lasts.

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