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Reducing Skin Booster Injection Pain, Part 2: Numbing Cream Time and Thickness

Dr. Ha Jaeseon·2026.09.29·2 min read
Reducing Skin Booster Injection Pain, Part 2: Numbing Cream Time and Thickness

How to make skin boosters (Rejuran, Rituo, Gouri, etc.) less painful

→ Apply anesthetic cream thickly and for a sufficient amount of time.

Hello, I am Dr. Ha Jaeseon, medical director of PO:VE Clinic.

Once you've chosen the type of anesthetic cream,

the next important factor is

how long you apply it.

In fact, according to FDA standards, even for minor procedures,

it is recommended to apply anesthetic cream for at least 1 hour.

Looking at related research (Depth of Cutaneous Analgesia After Application of a Eutectic Mixture of the

Local Anesthetics Lidocaine and Prilocaine, EMLA Cream),

it was found that skin biopsies (removing a small piece of skin for examination) were possible without pain

at depths of 1-2mm, 2-3mm, and 6mm when anesthetic cream was applied for 60 minutes, 120 minutes, and 3-4 hours, respectively.

This means that as the application time increases,

the depth of anesthesia also increases.

However, in reality, applying it for more than 1 hour

is quite difficult for patients.

Therefore, methods to reduce anesthesia time are often chosen,

such as applying the cream and then wrapping it,

and anesthesia is typically performed for about 20 minutes.

But even with wrapping,

20 minutes is an extremely short time.

This might be why Rejuran always felt so painful,

even though we always perform anesthesia.

Therefore, I ensure both increased absorption speed through wrapping

and a minimum anesthetic cream application time of 40 minutes.

(Because it hurts less... because it's the only way...)

Thickness is as important as time.

What's as important as time is how thickly you apply the anesthetic cream.

If you spread the anesthetic cream thinly,

the active ingredients in the cream will be depleted quickly.

Therefore, if applied thinly, the anesthetic agent will not sufficiently diffuse deep into the skin.

The anesthetic cream must be applied thickly

to ensure continuous absorption throughout the anesthesia period.

From now on, please check these points when receiving treatment.

1. How many minutes do you wait between applying the anesthetic cream and the procedure?

2. What kind of anesthetic cream is used?

The video below is a comical edit by our staff of me receiving treatment.....

Please watch it for fun.

The reason we set the anesthesia time to over 40 minutes

and apply the anesthetic cream thickly like a Seongsimdang cream cake (?)

is to reduce pain.

While the extended anesthesia time might feel tedious,

if you shorten that 40 minutes, you will ultimately pay the price (??) on the procedure table.

If I were to choose, I would opt for the comfortable procedure by investing an extra 20 minutes,

which is why our clinic still sets the anesthesia time

to over 40 minutes.

I hope everyone becomes beautiful with less pain.

In the next post, I will write about how to increase the absorption rate of anesthetic cream.

#Skin/Skin Boosters
Translated from the clinic’s Naver Blog. The Korean original is the reference text.Read the original on Naver Blog →
WRITTEN BY
Ha Jaeseon · Doctor

Family Medicine Specialist, Korea University Hospital.
Leads clinical practice at PO:VE on the principles of comfortable recovery and beauty that lasts.

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